Baseline Pulse Rate
History of Diabetes at Baseline
History of Hypertension at Baseline
History of Myocardial Infarction at Baseline
History of Angina at Baseline
History of Congestive Heart Failure at Baseline
History of Valvular Heart Disease at Baseline
Aspirin Use prior to Randomization
Prestroke Rankin
Patient Reported Prior Stroke at Baseline
Patient Reported Prior TIA at Baseline
Atrial Fibrillation at Admission
Treatment Code
Smoking in Year prior to This Stroke
No Preexisting Disability at Baseline
Baseline Systolic BP
Baseline Diastolic BP
Patient's Gender
Patient's Race
Estimated Weight (kg) at Randomization
Presumptive Diagnosis at Time of Treatment
Age in Years
Actual Weight (kg) Measured after Randomization
Serum Glucose at Baseline (mg/dl)
Fibrinogen at Baseline (mg/dl)
Edema on Baseline CT
Mass Effect on Baseline CT
Center Of Randomization
Study Randomization Stratum
Any Hemorrhage during Trial
Fatal Symptomatic Hemorrhage during Trial
Designation of Trial (Part I or II)
Barthel Index at 6 Months (Intent to Treat Imputation)
Modified Rankin Scale at 6 Months (Intent to Treat Imputation)
Glasgow at 6 Months (Intent to Treat Imputation)
Barthel Index at 12 Months (Intent to Treat Imputation)
Modified Rankin Scale at 12 Months (Intent to Treat Imputation)
Glasgow at 12 Months (Intent to Treat Imputation)
Rankin at 7-10 Days
Modified Rankin Scale at 90 Days (Intent to Treat Imputation)
Glasgow at 90 Days (Intent to Treat Imputation)
Barthel Index at 90 Days (Intent to Treat Imputation)
Primary Cause of Death
Days from randomization to death/censored
Indicates if Patient Died during Trial Follow-Up(Yes=dead)
History of Atherosclerosis at Baseline
Admission Systolic BP
Admission Diastolic BP
Drink Alcoholic Beverages at Baseline
NIH Stroke Scale at Baseline
Patient Reported Prior Stroke or Old Stroke on Baseline CT
History of Other Cardiac Disease at Baseline
Early Ischemic Stroke CT Findings(Edema or Mass Effect or Midline Shift or Intravascular Thrombus)on Baseline CT
Early Ischemic Stroke CT findings(Edema or Mass Effect or Midline Shift)on Baseline CT
Time from Stroke Onset to Treatment/Randomization (Minutes)
Admission Temperature
Drinking Problem defined by Cage Questionnaire
History of Hyperlipidemia at Baseline
History of Hepatic disease at Baseline
History of Malignancy at Baseline
History of Hematological Disease at Baseline
Drink In Past 24 Hrs
Total Dose Delievered (mg) (based on estimated weight)
Heparin Use prior Baseline Stroke
Prosthetic Heart Disease at Admission
Calcium Channel Blocker at Baseline
Baseline Pulse Pressure
Admission Pulse Pressure
Type of cancer
Hemorrhagic Infarctions during Trial
Intracerebral Hematomas during Trial
Hemorrhage (Symp. & Asymp.) during Trial
Time from Randomization to Hemrrohage(Minutes)
Likeliest Clinical Classification of Ischemic Stroke Based on Post Treatment Data (could be influenced by treatment)
Old Lesion Volume at Baseline(missing set to zero if patient had baseline CT)
3 month Lesion Volume(Intent to Treat)
Hyperdense Artery Sign on Baseline CT(reviewed with clinical information)
Loss of Gray-White Matter Distinction (GWMD) on Baseline CT(reviewed with clinical information)
Loss of GWMD over 33% of MCA on Baseline CT(reviewed with clinical information)
Presence of Hypodensity on Baseline CT(reviewed with clinical information)
Hypodensity over 33% of MCA on Baseline CT(reviewed with clinical information)
Compression of CSF Space on Baseline CT(reviewed with clinical information)
Compression of CSF over 33% of MCA on Baseline CT(reviewed with clinical information)
Early CT Findings(excluding hyperdense artery sign(also called intravascular thrombus))on Baseline CT(reviewed with clinical information)
Early CT Findings over 33% of MCA on Baseline CT(reviewed with clinical information)
Time from stroke onset to CT scan at baseline (minutes)
% of Correct Dose Administered (based on actual weight)
Midline Shift on Baseline CT
Hyperdense Ischemic Infarct on Baseline CT
Intravascular Thrombus on Baseline CT
Early CT Findings(Edema or Mass Effect or Midline Shift or Hyperdense Ischemic Infarct or Intravascular Thrombus)
Abnormal Baseline CT(Variable FINDINGS is Yes or Old Lesion at Baseline)
Old Lesion Volume at Baseline with Missing Set to Zero
The Place to Which Patient was Discharged after Initial Hospitalization
Length of Hospital Stay from Admission to Discharge (Days)
Admission Pulse Rate
Baseline Temperature
WBC at Baseline (/mm3)
HCT at Baseline (%)
Serum Na at Baseline (mEq/L)
Serum K at Baseline (mEq/L)
Serum BUN at Baseline (mg/dL)
Serum Creatinine at Baseline (mg/L)
Total Bilirubin at Baseline (mg/L)
New Ischemic Stroke (Reviewed at Coordinating Center)
Time from Treatment/Randomization to New Ischemic Stroke (Days)
Indicates if Baseline CT was of Sufficient Quality to Be Reviewed(Yes=reviewed)
Time from Stroke Onset to Admission(Seconds)
Time from Admission to Treatment/Randomization(Seconds)
Level of Consciousness at baseline
LOC Questions at baseline
LOC Commands at baseline
Best Gaze at baseline
Visual at baseline
Facial Palsy at baseline
Motor Left Arm at baseline
Motor Right Arm at baseline
Motor Left Leg at baseline
Motor Right Leg at baseline
ATAXIA score at baseline
Sensory at baseline
Best Language at baseline
Dysarthria at baseline
Extinction And Inattention at baseline
Level of Consciousness at 2 hours post treatment(missing imputed)
LOC Questions at 2 hours post treatment(missing imputed)
LOC Commands at 2 hours post treatment(missing imputed)
Best Gaze at 2 hours post treatment(missing imputed)
Visual at 2 hours post treatment(missing imputed)
Facial Palsy at 2 hours post treatment(missing imputed)
Motor Left Arm at 2 hours post treatment(missing imputed)
Motor Right Arm at 2 hours post treatment(missing imputed)
Motor Left Leg at 2 hours post treatment(missing imputed)
Motor Right Leg at 2 hours post treatment(missing imputed)
ATAXIA score at 2 hours post treatment(missing imputed)
Sensory at 2 hours post treatment(missing imputed)
Best Language at 2 hours post treatment(missing imputed)
Dysarthria at 2 hours post treatment(missing imputed)
Extinction And Inattention at 2 hours post treatment(missing imputed)
Level of Consciousness at 24 hours post stroke onset(missing imputed)
LOC Questions at 24 hours post stroke onset(missing imputed)
LOC Commands at 24 hours post stroke onset(missing imputed)
Best Gaze at 24 hours post stroke onset(missing imputed)
Visual at 24 hours post stroke onset(missing imputed)
Facial Palsy at 24 hours post stroke onset(missing imputed)
Motor Left Arm at 24 hours post stroke onset(missing imputed)
Motor Right Arm at 24 hours post stroke onset(missing imputed)
Motor Left Leg at 24 hours post stroke onset(missing imputed)
Motor Right Leg at 24 hours post stroke onset(missing imputed)
ATAXIA score at 24 hours post stroke onset(missing imputed)
Sensory at 24 hours post stroke onset(missing imputed)
Best Language at 24 hours post stroke onset(missing imputed)
Dysarthria at 24 hours post stroke onset(missing imputed)
Extinction And Inattention at 24 hours post stroke onset(missing imputed)
Level of Consciousness at 7-10 days post stroke onset(missing imputed)
LOC Questions at 7-10 days post stroke onset(missing imputed)
LOC Commands at 7-10 days post stroke onset(missing imputed)
Best Gaze at 7-10 days post stroke onset(missing imputed)
Visual at 7-10 days post stroke onset(missing imputed)
Facial Palsy at 7-10 days post stroke onset(missing imputed)
Motor Left Arm at 7-10 days post stroke onset(missing imputed)
Motor Right Arm at 7-10 days post stroke onset(missing imputed)
Motor Left Leg at 7-10 days post stroke onset(missing imputed)
Motor Right Leg at 7-10 days post stroke onset(missing imputed)
ATAXIA score at 7-10 days post stroke onset(missing imputed)
Sensory at 7-10 days post stroke onset(missing imputed)
Best Language at 7-10 days post stroke onset(missing imputed)
Dysarthria at 7-10 days post stroke onset(missing imputed)
Extinction And Inattention at 7-10 days post stroke onset(missing imputed)
Level of Consciousness at 3 months post stroke onset(missing imputed)
LOC Questions at 3 months post stroke onset(missing imputed)
LOC Commands at 3 months post stroke onset(missing imputed)
Best Gaze at 3 months post stroke onset(missing imputed)
Visual at 3 months post stroke onset(missing imputed)
Facial Palsy at 3 months post stroke onset(missing imputed)
Motor Left Arm at 3 months post stroke onset(missing imputed)
Motor Right Arm at 3 months post stroke onset(missing imputed)
Motor Left Leg at 3 months post stroke onset(missing imputed)
Motor Right Leg at 3 months post stroke onset(missing imputed)
ATAXIA score at 3 months post stroke onset(missing imputed)
Sensory at 3 months post stroke onset(missing imputed)
Best Language at 3 months post stroke onset(missing imputed)
Dysarthria at 3 months post stroke onset(missing imputed)
Extinction And Inattention at 3 months post stroke onset(missing imputed)
NIH Stroke Scale at 2 Hours (missing = Alive w/o data)
NIH Stroke Scale at 24 Hours (missing = Alive w/o data)
NIH Stroke Scale at 7-10 Days (missing = Alive w/o data)
NIH Stroke Scale at 90 Days (Intent to Treat Imputation)
NIH Stroke Scale at 2 hours post treatment(missing = Death or Alive w/o data)
NIH Stroke Scale at 24 hours post stroke onset(missing = Death or Alive w/o data)
NIH Stroke Scale at 7-10 days post stroke onset(missing = Death or Alive w/o data)
NIH Stroke Scale at 3 months post stroke onset(missing = Death or Alive w/o data)
=1 if one or more of NIH Stroke Scale individual items at 2 hours post treatment are imputed
=1 if one or more of NIH Stroke Scale individual items at 24 hours post stroke onset are imputed
=1 if one or more of NIH Stroke Scale individual items at 7-10 days post stroke onset are imputed
=1 if one or more of NIH Stroke Scale individual items at 3 months post stroke onset are imputed
NIH Stroke Scale at 2 hours post treatment(missing imputed)
NIH Stroke Scale at 24 hours post stroke onset(missing imputed)
NIH Stroke Scale at 7-10 days post stroke onset(missing imputed)
NIH Stroke Scale at 3 months post stroke onset(missing imputed)
Barthel Index at 7-10 Days (Intent to Treat Imputation)
NIH Stroke Scale at Baseline(8 groups)
NIH Stroke Scale at Baseline(5 groups)
Handedness
Location Hemisphere
3m lesion volume imputed
7-10 days lesion volume imputed
24 hours lesion volume imputed
=1 if symptomatic/asymptomatic hemorrhage occurred within 36 hours from initiation of treatment
=1 if symptomatic hemorrhage occurred within 36 hours from initiation of treatment
Died 24 hrs post stroke onset
Died 2 hrs post stroke onset
Died 7 days post treatment onset
Died 90 days post treatment onset
NIH S.S at Baseline
Antihypertensive treatment (Post-randomization)
Antihypertensive treatment (Pre-randomization)
Post Antihypertensive treatment Required based on data (Postrandomization hypertension)
Post randomization Diastolic blood pressure >=90
MBP drops 20 pts
The largest Drop of mean blood pressure in 24 hrs
The largest Drop of mean blood pressure from baseline
The largest Concsecutive mean blood pressure drop in first 8 hrs
The maximum mean blood pressure in 24 hrs
Antihypertensive medication given before/after Randomization
Admission Sys. BP>185 or Dia. BP>110 (Prerandomization hypertension)
Admission diastolic blood pressure >= 90 mmHg
Pre or post randomization Diastolic blood pressure >=90
Hypertension before/after randomization
NIH Stroe Scale difference (baseline - 24 hours)
Scale change at 24 hours
NIH Stroke Scale <=1 at 3 90 days (Intent to Treat Imputation)
Barthel Index >=95 at 90 Days (Intent to Treat Imputation)
Modified Rankin Scale=(0,1) at 90 Days (Intent to Treat Imputation)
Glasgow =1 at 90 Days (Intent to Treat Imputation)
7-10 day Lesion Volume(Intent to Treat)
24 hours Lesion Volume (int. to treat)
Baseline CT Lesion Volume
Edema on 24 hour CT
Mass Effect on 24 hour CT
Midline Shift on 24 hour CT
Hyperdense Ischemic Infarct on 24 hour CT
Intravascular Thrombus on 24 hour CT
24 hours CT lesion volume (raw)
7-10 days CT lesion volume (raw)
3 month CT lesion volume (raw)
All DFI
Cause of DFI
Time from Treatment/Randomization to DFI (Hours)
DFI (Reocclusion)
DFI (otherwise)
DFI within 24 hrs
DFI (Reocclusion) in 24 hrs
DFI (otherwise) in 24 hrs
Deterioration at 24 hrs
Deterioration at 7-10d
FDP, mcg/ml
NIH Stroe Scale difference (baseline - 90 days)
Intetvals of Time from Randomization to Hemrrohage(Hours)
=1 if asymptomatic hemorrhage occurred within 36 hours from initiation of treatment
NIHSS Item <2, LOC=0
Presumed Small
No LOC, Visual, Aphasia, Hemianopia, Neglect
SS<=9 & No LOC, Visual, Aphasia, Hemianopia, Neglect
SS<=9 only
Barthel Index - Feeding (7-10 days post stroke onset)
Barthel Index - Moving (7-10 days post stroke onset)
Barthel Index - Personal Toilet (7-10 days post stroke onset)
Barthel Index - On Off Toilet (7-10 days post stroke onset)
Barthel Index - Bathing (7-10 days post stroke onset)
Barthel Index - Walking (7-10 days post stroke onset)
Barthel Index - Wheelchair (7-10 days post stroke onset)
Barthel Index - Stairs (7-10 days post stroke onset)
Barthel Index - Dressing (7-10 days post stroke onset)
Barthel Index - Bowels (7-10 days post stroke onset)
Barthel Index - Bladder (7-10 days post stroke onset)
Barthel Index - Feeding (3 months post stroke onset)
Barthel Index - Moving (3 months post stroke onset)
Barthel Index - Personal Toilet (3 months post stroke onset)
Barthel Index - On Off Toilet (3 months post stroke onset)
Barthel Index - Bathing (3 months post stroke onset)
Barthel Index - Walking (3 months post stroke onset)
Barthel Index - Wheelchair (3 months post stroke onset)
Barthel Index - Stairs (3 months post stroke onset)
Barthel Index - Dressing (3 months post stroke onset)
Barthel Index - Bowels (3 months post stroke onset)
Barthel Index - Bladder (3 months post stroke onset)
Barthel Index - Feeding (6 months post stroke onset)
Barthel Index - Moving (6 months post stroke onset)
Barthel Index - Personal Toilet (6 months post stroke onset)
Barthel Index - On Off Toilet (6 months post stroke onset)
Barthel Index - Bathing (6 months post stroke onset)
Barthel Index - Walking (6 months post stroke onset)
Barthel Index - Wheelchair (6 months post stroke onset)
Barthel Index - Stairs (6 months post stroke onset)
Barthel Index - Dressing (6 months post stroke onset)
Barthel Index - Bowels (6 months post stroke onset)
Barthel Index - Bladder (6 months post stroke onset)
Barthel Index - Feeding (12 months post stroke onset)
Barthel Index - Moving (12 months post stroke onset)
Barthel Index - Personal Toilet (12 months post stroke onset)
Barthel Index - On Off Toilet (12 months post stroke onset)
Barthel Index - Bathing (12 months post stroke onset)
Barthel Index - Walking (12 months post stroke onset)
Barthel Index - Wheelchair (12 months post stroke onset)
Barthel Index - Stairs (12 months post stroke onset)
Barthel Index - Dressing (12 months post stroke onset)
Barthel Index - Bowels (12 months post stroke onset)
Barthel Index - Bladder (12 months post stroke onset)
Barthel Index score(7-10 days post stroke onset)
Barthel Index at 3 months (raw)
Barthel Index at 6 months (raw)
Barthel Index at 12 months (raw)
Admission Mean Arterial Blood Pressure = (Admission Systolic BP + 2*Admission Diastolic BP)/3
Modified Rankin Scale at 90 Days (raw)
Glasgow at 90 Days (raw)
Modified Rankin Scale at 6 Months (raw)
Glasgow at 6 Months (raw)
Modified Rankin Scale at 12 Months (raw)
Glasgow at 12 Months (raw)